FRMD4A, variants, traits, and what the research shows

FRMD4A - what this gene does

Based on the variant data catalogued to date, FRMD4A is a gene whose research footprint spans an unusually wide set of trait areas - neurological conditions carry the strongest signals, but the variant portfolio also touches metabolic health, respiratory outcomes, immune function, cardiovascular traits, mental health, cancer susceptibility, kidney-related phenotypes, and rare disease.

Key takeaways

• The two highest-magnitude signals for this gene both fall in the neurological trait category, giving brain-related associations the strongest overall evidence weight
• Three separate variants point to cancer-related traits
• Metabolic, respiratory, and immune traits each appear across two independent variants within this gene, offering partial within-category replication
• The variant profile covers nine distinct trait categories across 149 catalogued variants
• All findings are population-level statistical associations; none determine individual health outcomes

Notable variants

The two top-ranked signals are both neurological: rs869025338 (magnitude 5.50) and rs2491122657 (magnitude 5.00). At the next tier of evidence strength, metabolic associations appear at rs10796166 and rs12570849, while respiratory phenotypes are linked to rs11258524 and rs1881586. Three cancer-related signals cluster together: rs576948661, rs77472219, and rs78590946. A rare-disease association at rs143732408, a kidney-related signal at rs192300145, and a mental-health variant at rs56227933 each represent single-variant signals in their respective categories.

Trait associations

Neurological conditions carry the strongest overall signal weight, represented by rs869025338 and rs2491122657. Metabolic traits appear at both rs10796166 and rs12570849, and respiratory phenotypes are flagged at rs11258524 and rs1881586 - two-variant coverage in each of these categories offers some within-gene signal consistency, though independent-cohort replication data is not available in the current dataset. Immune function is represented by rs181176160 and rs7911501. Cancer susceptibility appears across three variants - rs576948661, rs77472219, and rs78590946. Cardiovascular (rs12777098), mental health (rs56227933), kidney (rs192300145), and rare disease (rs143732408) each have a single catalogued variant.

Evidence quality

Of 149 total catalogued variants, 27 have research summaries on file; published editorial pages exist for rs11819533, rs11258524, and rs10796166, though their detailed content was not available for incorporation here. Specific effect sizes (such as odds ratios or beta coefficients), sample sizes, and multi-cohort replication status are not captured in the current data for most variants. The top neurological signals - rs869025338 and rs2491122657 - rank highest by combined magnitude and evidence weighting, but should be treated as preliminary GWAS (genome-wide association study - a method that scans hundreds of thousands of genetic variants across large populations to find statistical links to traits) findings pending fuller characterization. The breadth of nine trait categories is notable but should not be interpreted as confirmed multi-system biological involvement without deeper per-variant evidence.

What this is NOT

These variants are population-level statistical associations, not deterministic predictors of any individual's health trajectory. This page does not constitute medical advice, a diagnosis, or any recommendation to take action.