FMO1-AS1, variants, traits, and what the research shows

FMO1-AS1 - what this gene does

FMO1-AS1 is a gene locus whose catalogued variants span trait themes including vision, respiratory function, metabolic processes, cardiovascular traits, and coagulation - based on GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically associated with a trait) data on file.

Key takeaways

• The strongest variants at this locus are linked to vision and respiratory traits.
• Five separate variants point to metabolic associations, making metabolism the most numerically represented theme.
• Cardiovascular and coagulation traits each appear in at least one variant at this locus.
• 56 variants are catalogued here, with 24 carrying published research context.
• All findings are population-level statistical signals, not predictors for any individual.

Notable variants

The four highest-magnitude variants on file each carry a magnitude score of 4.50: rs10800543, linked to vision; rs72482608, linked to respiratory traits; and rs142988848 and rs1795240, for which trait details are not currently available. The next strongest signal is rs10800558 (magnitude 2.80), also associated with vision, suggesting some convergence of the vision signal at this locus. At magnitude 2.20, a broader cluster includes cardiovascular-linked rs10919470, coagulation-linked rs10919507, and metabolic-linked variants rs10753824, rs10800544, rs10919526, rs11802891, and rs12044055.

Trait associations

Vision is the most prominently represented trait at this locus, with three variants - rs10800543, rs10800558, and rs10919476 - each flagged for eye-related associations; two of those carry the highest magnitude scores in the dataset. Metabolic traits appear across five variants (rs10753824, rs10800544, rs10919526, rs11802891, rs12044055), making metabolism the most numerically represented theme. Respiratory association is carried by rs72482608, cardiovascular by rs10919470, and coagulation (the process by which blood forms clots) by rs10919507.

Evidence quality

The strongest signals - magnitude 4.50 at rs10800543 and rs72482608 - represent the best-evidenced associations on file; however, full study details for variants at this locus (effect sizes, sample sizes, replication cohorts) are not available here, so confidence in these specific links cannot be further quantified. The remaining catalogued variants cluster at magnitude 2.20, a level that typically reflects modest GWAS signals that benefit from independent replication before firm conclusions are drawn. With 56 total variants and trait themes spread across five distinct categories, this locus appears pleiotropic (associated with more than one trait), but that observation should be interpreted cautiously until complete study data are published.

What this is NOT

These variants are population-level statistical signals from GWAS studies, not deterministic predictors of any outcome for any individual. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.