FHIT, variants, traits, and what the research shows

FHIT - what this gene does

Variants in this gene are associated with traits spanning cardiovascular health, cancer risk, kidney function, hormonal regulation, and liver conditions, based on the research-linked variants catalogued here.

Key takeaways

• Multiple independent cancer-related signals have been catalogued across this gene's variant set.
• Cardiovascular trait associations appear across three separate variants, adding consistency to that theme.
• Liver-related traits are represented by two variants sharing the same magnitude rating.
• Kidney and hormonal trait associations each appear as single independent signals.
• All catalogued variants carry the same magnitude score, indicating a consistent evidence tier across the gene.

Notable variants

Four variants - rs139239158, rs145467611, rs2366964, and rs771419899 - are linked to cancer-related traits, representing the strongest thematic cluster in this gene's variant set. Cardiovascular trait associations appear independently across rs115227607, rs138741635, and rs727476. Liver conditions are flagged at rs766488186 and rs77718937. A kidney-related signal is present at rs144504132, and a hormonal trait association appears at rs186677894.

Trait associations

Cancer-related traits appear across four variants - rs139239158, rs145467611, rs2366964, and rs771419899 - making cancer the most recurrent theme in this gene's catalogued associations. Cardiovascular traits are linked to rs115227607, rs138741635, and rs727476, providing three independent data points in that category. Liver conditions appear at two sites - rs766488186 and rs77718937. Kidney function is flagged at rs144504132, and hormonal traits at rs186677894. Several additional variants - including rs114807731 and rs212016 - carry the same magnitude rating without a trait label in the current dataset.

Evidence quality

All variants with research summaries on file share a magnitude score of 4.50, indicating a uniform evidence tier across the gene. The full catalogue holds 192 variants, of which 21 carry prior research summaries; the remainder lack detailed trait metadata in the current dataset. No sample sizes, odds ratios, or replication-status details are available in the supplied data, so the relative strength of individual associations cannot be ranked beyond the shared magnitude score. Findings should be treated as preliminary signals pending fuller published detail for each variant.

What this is NOT

These variants are population-level statistical signals - not deterministic predictors for any individual - and carrying any of these variants does not mean a person will develop any associated condition. This page does not prescribe, diagnose, or advise any course of action.