FANK1, variants, traits, and what the research shows

FANK1 - what this gene does

Based on currently catalogued variant data, FANK1 shows its clearest trait signal in neurological research, with 79 variants on file spanning a range of effect-size magnitudes. Trait annotations remain unpublished for the majority of those variants, so the full biological picture is still emerging.

Key takeaways

• FANK1 has 79 catalogued variants, with effect-size magnitudes ranging from 2.20 to 4.50 in this dataset.
• The highest-magnitude variant is rs11244757 (magnitude 4.50), the strongest signal in the gene's current profile.
• rs10794047 (magnitude 2.20) is the only variant in this dataset with a published trait label, linked to neurological traits.
• Eighteen additional variants each carry a magnitude of 3.00; trait annotations for these are not yet available.
• These are population-level statistical signals, not individual health predictors.

Notable variants

The strongest signal on file is rs11244757, carrying a magnitude of 4.50 - the highest in the gene's current catalogue; a published page exists for this variant, though its trait details were not available in the input data at time of writing. rs10794047 (magnitude 2.20) is the only variant with a confirmed trait label, associated with neurological traits. A cluster of 18 additional variants - including rs1319396630, rs1327630143, rs202054807, rs370689389, rs537760312, and rs774229266 among others - each score a magnitude of 3.00, but no trait annotations are currently on file for them.

Trait associations

The only trait theme available in the current dataset is neurological, linked to rs10794047. No trait labels are presently published for the remaining variants, including the top-ranked rs11244757. Because a trait annotation for a single variant represents a narrow evidence base, this association should be treated as preliminary until additional variants acquire trait labels and independent replication is reported.

Evidence quality

rs11244757 is the highest-magnitude entry (4.50) across all 79 on-file variants, indicating a comparatively large effect size in the underlying GWAS - a genome-wide association study (a study that scans many people's genomes for variants statistically linked to a trait) - though the specific trait and study details were not accessible at time of writing. rs10794047 carries a neurological trait tag at magnitude 2.20; its published page exists but no summary content was available at time of writing. For the 18 magnitude-3.00 variants, neither trait annotations nor study metadata are currently published, making it impossible to characterize their replication status or evidence strength.

What this is NOT

The variants listed here are population-level statistical signals, not deterministic predictors of any individual's biology or health outcomes. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.