FAM13A, variants, traits, and what the research shows

FAM13A - what this gene does

FAM13A (Family With Sequence Similarity 13 Member A, also referred to at the 4q22 chromosomal locus) is a gene whose variants have surfaced across genome-wide association studies (GWAS - studies that scan hundreds of thousands of people's genomes for variants statistically linked to a trait) in connection with a notably broad set of trait themes: cancer, respiratory function, metabolic processes, blood coagulation, and mental health.

Key takeaways

• Variants in this gene have been statistically associated with at least five distinct trait categories: cancer, respiratory, metabolic, coagulation, and mental health.
• The top-magnitude variant on file is linked to cancer and carries the strongest association signal in the gene.
• Separate high-magnitude variants each flag a different trait domain, suggesting this gene appears across multiple areas of population genomics research.
• All associations are population-level statistical signals - they are not deterministic predictors for any individual.
• Effect sizes and replication data are not available for individual variants in the current dataset, so all signals should be treated as preliminary.

Notable variants

The highest-magnitude variant in this gene is rs377446507 (magnitude 5.50), associated with cancer. A cluster of variants at magnitude 4.50 spans multiple distinct trait domains: rs7690881 is linked to respiratory traits, rs576406049 to metabolic traits, rs564709352 to coagulation (the biological process by which blood forms clots), and rs77033326 to mental health. Four additional magnitude-4.50 variants - rs11737260, rs2704588, rs6825998, and rs6835979 - are also on record, though specific trait labels for these are not available in the current dataset.

Trait associations

Five trait themes emerge from the variant data. Cancer is flagged by rs377446507, the top-magnitude entry in the gene. Respiratory associations are represented by rs7690881. Metabolic traits appear through rs576406049. Coagulation is implicated by rs564709352. Mental health associations are flagged by rs77033326. An additional tier of magnitude-3.00 variants is also on file - including rs116703634, rs1221890272, rs1223331892, and others - though trait annotations are not available for this tier in the current dataset.

Evidence quality

The strongest individual signal is rs377446507 at magnitude 5.50, associated with cancer. The remaining high-priority variants sit at magnitude 4.50 and each map to a different trait domain. The current dataset does not include effect sizes (such as odds ratios or beta coefficients) or sample sizes for individual variants, which limits the ability to characterize association strength precisely. No multi-cohort replication status is available from the current input, and it is not possible to distinguish single-cohort GWAS hits from more robustly replicated signals on the basis of the available data. All associations should be treated as preliminary findings pending confirmation of effect sizes and independent replication.

What this is NOT

These variants are population-level statistical signals from GWAS, reflecting average patterns across large groups, and are not deterministic predictors of any health outcome for any individual. This page does not prescribe, diagnose, or advise any course of action.