EVI5, variants, traits, and what the research shows

EVI5 - what this gene does

EVI5 (Ecotropic Viral Integration Site 5) is a human gene whose documented variants cluster around metabolic trait associations in genome-wide association studies (GWAS - studies that scan many people's genomes for variants statistically linked to a trait). The specific metabolic phenotypes are not resolved in the available dataset, but the gene's strongest signals consistently carry metabolic annotations.

Key takeaways

• Multiple variants in this gene are linked to metabolic traits in population-level genetic research.
• Five variants share the highest magnitude score in the current dataset and all carry metabolic trait annotations.
• Over 115 variants have been catalogued in this gene, with 22 carrying prior research summaries.
• Four of the top-tier variants have published research pages, indicating active scientific interest.
• These are population-level statistical signals, not predictions for any individual.

Notable variants

The five highest-magnitude variants - rs10735781, rs111289258, rs11164811, rs1176740948, and rs3903212 - each carry a magnitude score of 4.50 and are annotated with metabolic trait associations. A sixth variant at the same magnitude tier, rs6603991, reaches the same score but lacks a trait annotation in the current dataset. A broader set of variants - including rs1283685554, rs138806513, rs141479784, and rs142784307 - carry magnitude scores of 3.00, though their trait associations are not detailed in the available data.

Trait associations

The primary trait theme visible across this gene's variant data is metabolic. Five independent variants - rs10735781, rs111289258, rs11164811, rs1176740948, and rs3903212 - all share this annotation at the highest magnitude tier. The convergence of multiple independent variants on the same trait category adds consistency to the overall signal. The specific metabolic phenotypes (for example, which biomarkers or clinical conditions are implicated) are not resolved in the current summary data.

Evidence quality

Four of the five top-tier variants (rs10735781, rs111289258, rs11164811, rs1176740948) have published editorial pages, indicating they are better-characterized signals with prior research attention. All five share an identical magnitude score of 4.50, the strongest tier represented in this dataset. However, specific sample sizes, odds ratios, beta coefficients, and multi-cohort replication status are not provided in the current summary, so the depth of evidence behind each variant cannot be fully assessed here. The 115 total catalogued variants, with 22 carrying prior research summaries, reflect active and ongoing research interest, but most variants' trait contexts remain unpublished in this dataset.

What this is NOT

These variants are population-level statistical signals derived from GWAS analyses and are not deterministic predictors of any outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any action.