ESRRG, variants, traits, and what the research shows

ESRRG - what this gene does

Variants in ESRRG cluster across several biological trait themes - including mental health, neurological function, pharmacogenomics (how the body processes certain medicines), respiratory traits, cancer, and athletic performance - based on the associations documented in the data below.

Key takeaways

• Two high-magnitude ESRRG variants are independently linked to mental health traits, adding modest consistency to that association.
• Three variants fall under pharmacogenomics, suggesting possible relevance to how some individuals respond to certain drugs.
• Additional high-magnitude variants connect this gene to neurological function, respiratory traits, cancer, and athletic performance.
• All associations come from GWAS (genome-wide association studies - large scans of many people's DNA for statistically linked variants) and describe population-level patterns, not individual outcomes.
• Over 100 variants are catalogued in this gene, but detailed study data is limited for most of them.

Notable variants

The highest-magnitude signals (each rated 4.50) include rs10779271 and rs2377360, both tagged with mental health associations - two independent hits within the same gene pointing toward the same trait domain. rs1953522 carries a neurological trait label. Three variants share a pharmacogenomics classification: rs147472650, rs150859230, and rs74542326. Rounding out the top-magnitude tier, rs34063124 is linked to a respiratory trait, rs4085154 to cancer, and rs7529338 to an athletic phenotype. rs12126082 and rs1339221 share the same magnitude rating but carry no trait label in the available data.

Trait associations

• Mental health: rs10779271 and rs2377360 both carry this label at the highest magnitude tier, providing within-gene replication that modestly strengthens the signal.
• Neurological: rs1953522 is associated with a neurological trait.
• Pharmacogenomics: rs147472650, rs150859230, and rs74542326 are each classified under this category.
• Respiratory: rs34063124 carries a respiratory trait label.
• Cancer: rs4085154 is linked to a cancer-related trait.
• Athletic performance: rs7529338 is associated with an athletic phenotype.

Additional variants at lower magnitude (3.00) - including rs1194634049, rs1282220595, rs1287921361, rs144069220, and others - are on file without trait labels.

Evidence quality

The strongest signals carry a magnitude of 4.50, shared across 11 variants spanning multiple trait domains. Within-gene replication exists for two themes: mental health is supported by two independent variants (rs10779271 and rs2377360), and pharmacogenomics by three (rs147472650, rs150859230, rs74542326). However, the published SNP summaries available for this gene contain no information on study design, sample sizes, cohort composition, or effect sizes - so the depth and robustness of the evidence base cannot be assessed beyond trait labels and magnitude scores. Many of the 102 variants on file lack trait metadata entirely, and the majority of the lower-magnitude (3.00) variants have no editorial context at all. These gaps are significant: trait labels without effect sizes or replication details leave the biological and clinical interpretation of these associations largely open.

What this is NOT

These variants are population-level statistical signals from large genetic studies, not deterministic predictors of any trait or condition for any individual person. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.