ERC2, variants, traits, and what the research shows

ERC2 - what this gene does

ERC2 is a gene whose catalogued variants point to two recurring trait themes in population-level genomic research: mental health conditions and, to a lesser degree, respiratory traits. No prior SNP-level summaries are available in the current dataset, so the characterisation below rests entirely on the variant list and its trait labels.

Key takeaways

• Seven of the eleven strongest variants in this gene are linked to mental health traits, making that the dominant association theme
• Two top-ranked variants are associated with respiratory traits
• All top-tier variants reach a magnitude score of 4.50 - the highest on file for this gene
• 182 variants are catalogued in total; detailed effect-size data is not yet available for individual variants
• All associations are population-level statistical signals and do not predict health outcomes for any individual

Notable variants

Seven variants tied to mental health traits sit at the highest magnitude level on file (4.50): rs12496267, rs2316482, rs6810099, rs71309948, rs7623143, rs7641315, and rs78731704. On the respiratory side, rs2132237 and rs7641482 share the same top magnitude score. Two further top-tier variants - rs55705711 and rs7628951 - do not yet carry trait labels in the current dataset and are noted here for completeness.

Trait associations

Mental health traits dominate: seven of the eleven highest-magnitude variants - rs12496267, rs2316482, rs6810099, rs71309948, rs7623143, rs7641315, and rs78731704 - share that classification. The clustering of multiple distinct variants under the same trait theme is consistent with, though does not confirm, a meaningful relationship between this gene and mental health biology. Respiratory traits form a secondary theme, represented by rs2132237 and rs7641482 at the same top magnitude tier.

Evidence quality

A total of 182 variants are on file for this gene, of which 19 carry prior research annotations; none have SNP-level summaries in the current dataset. The eleven highest-ranked variants all score at magnitude 4.50, while a second tier of nine variants (rs139250346, rs1410926083, rs1467445236, rs184802404, rs200184138, rs200582069, rs200893263, rs201496750, and rs201572436) reaches 3.00. Because detailed study metadata - odds ratios (a measure of how much a variant changes statistical odds of a trait), sample sizes, and replication status - are not yet available, it is not possible to determine whether these signals come from large multi-cohort GWAS (genome-wide association studies - research that scans many people's genomes for variants statistically associated with a trait) or smaller single-cohort analyses. All associations should be treated as preliminary until SNP-level pages are populated.

What this is NOT

These variants are population-level statistical associations drawn from genomic studies and are not deterministic predictors of any individual's health or disease risk. Nothing on this page constitutes medical advice, a clinical diagnosis, or a recommendation for any action.