EBF1, variants, traits, and what the research shows

EBF1 - what this gene does

Variants at the EBF1 locus (the specific chromosomal position of this gene) have been catalogued in relation to trait themes spanning cardiovascular health, nutritional factors, and liver-related measurements, based on 145 variants currently on file.

Key takeaways

• This gene carries 145 catalogued variants, with the strongest signals pointing to cardiovascular health, nutritional traits, and liver-related measurements.
• The four highest-magnitude variants include links to cardiovascular health, nutrition, and liver function.
• No detailed study data, including effect sizes or sample sizes, is currently available - treat all findings as preliminary.
• These are population-level statistical signals, not personal health predictions.
• Many variants at this locus still await trait annotation.

Notable variants

The four highest-magnitude variants each carry a magnitude score of 4.50. Among them, rs149148360 is linked to a cardiovascular trait, rs536115678 to a nutritional trait, and rs6898290 to a liver-related trait. The fourth top-magnitude variant, rs13167291, carries the same 4.50 score but no trait label is recorded in the current dataset. A further group including rs144663267, rs149065953, rs748539172, rs749897481, and rs755850355 each carry a magnitude score of 3.00, with no specific trait annotations available at this time.

Trait associations

The trait themes represented in the current catalogue for this gene include cardiovascular health (rs149148360), nutritional factors (rs536115678), and liver-related measurements (rs6898290). Each of these three themes appears in one of the four top-magnitude variants. The remaining magnitude-3.00 variants, including rs1010503968, rs1170847073, rs1446440015, and rs201413959, carry no trait labels in the current dataset, limiting further trait inference from this locus.

Evidence quality

No detailed study summaries, such as odds ratios (a measure of how much a variant changes the statistical odds of a trait), beta coefficients, sample sizes, or replication cohort information, are currently available for any variant at this locus. The trait annotations for the three labeled top-magnitude variants (rs149148360 cardiovascular, rs536115678 nutrition, rs6898290 liver) represent the full extent of documented trait data in the current dataset. Without study-level metadata, it is not possible to characterize effect sizes, population scope, or replication status for any of the 145 variants on file. All associations described here should be treated as preliminary until further study-level data becomes available.

What this is NOT

These variants are population-level statistical signals from GWAS (genome-wide association studies that scan large groups of people's genomes for variants statistically linked to traits), not deterministic predictors of outcomes for any individual. We do not prescribe, diagnose, or advise any action based on this information.