DPP10, variants, traits, and what the research shows

DPP10 - what this gene does

Variants across this gene appear in genome-wide association studies (GWAS - a type of study that scans large populations for genetic variants statistically linked to traits) connected to cancer, liver conditions, mental health, pharmacogenomics (how genetic variation shapes drug response), and cardiovascular traits.

Key takeaways

• Cancer-related associations appear across multiple independent variants in this gene, adding weight compared to a single finding alone.
• Liver-related and pharmacogenomic signals are also among the highest-magnitude variants currently on file.
• Mental health associations are represented by at least two separate variants.
• A cardiovascular trait signal rounds out a notably broad trait profile.
• All of these are population-level statistical associations, not individual predictions.

Notable variants

Among the highest-magnitude findings, rs114830967 is linked to pharmacogenomics and carries a published research page. rs115408977, at the same magnitude tier, carries a cancer association and also has a published page. Cancer signals appear independently at rs17048372 and rs193199270 as well, suggesting the cancer connection is not limited to a single variant. Mental health associations surface at rs4308128 and rs190662943. A liver-related signal is present at rs7599434, and rs4849384 carries a cardiovascular trait label.

Trait associations

Cancer is the most heavily represented trait theme, with seven variants at the top magnitude tier carrying cancer labels: rs115408977, rs138941884, rs140196981, rs17048372, rs192750724, rs193199270, and rs548197650. The repetition of a trait across separate variants strengthens - though does not confirm - the overall signal. Liver conditions are represented by three top-tier variants: rs140454687, rs72839255, and rs7599434. Mental health associations appear at rs4308128 and rs190662943. Pharmacogenomics is represented by rs114830967, and cardiovascular traits by rs4849384.

Evidence quality

Of the 126 variants catalogued for this gene, 17 carry prior research annotations; the two with fully published pages are rs114830967 and rs115408977. Specific effect sizes, odds ratios, and sample sizes are not yet available in the current dataset for most variants, which limits the ability to characterize association strength beyond the magnitude tier score. The spread of trait themes - cancer, liver, mental health, pharmacogenomics, cardiovascular - suggests diverse research interest, but without study-level detail for each variant, replication status and cohort sizes cannot be confirmed here. Treat all associations as preliminary signals pending fuller documentation.

What this is NOT

These variants are population-level statistical signals drawn from large-group studies, not deterministic predictors of any outcome for any individual. This encyclopedia entry does not prescribe, diagnose, or advise any course of action.