DOCK7-DT, variants, traits, and what the research shows

DOCK7-DT - what this gene does

DOCK7-DT is a human gene locus whose catalogued variants are statistically linked to a cluster of traits spanning metabolism, nutritional biomarkers, blood coagulation (the process by which blood forms clots), and kidney function. No mechanistic characterization is available from the current variant data, so the description here is limited to those observed trait associations.

Key takeaways

• Variants near this gene show up in genome-wide association studies (GWAS - studies that scan large populations for statistical links between genetic variants and traits) across four trait themes: metabolism, nutrition, blood coagulation, and kidney function.
• Metabolic associations are the most represented signal, spread across five separate variants at this locus.
• Nutritional biomarker links appear at four variants and may overlap with the metabolic signal given their proximity in the genome.
• One variant at this locus carries a coagulation-related association, making it the only blood-clotting signal in the current dataset.
• All catalogued variants carry a uniform magnitude score of 2.20, consistent with modest GWAS-level effect sizes.

Notable variants

The metabolic signal is carried by rs10889356, rs10889357, rs1168107, rs12130333, and rs372296345. Nutrition-linked variants include rs10889360, rs11208007, rs11208009, and rs12136083. The coagulation association is carried by rs1168114, while kidney-related signals appear at rs12124310 and rs4915853.

Trait associations

Metabolic traits form the largest category at this locus, appearing across rs10889356, rs10889357, rs1168107, rs12130333, and rs372296345. Recurrence across five variants strengthens the case that this region participates in metabolic biology, though the specific pathways involved are not characterized in the available data. Nutritional biomarker associations appear at rs10889360, rs11208007, rs11208009, and rs12136083, and their proximity to the metabolic variants may reflect shared underlying biology. Kidney function associations are noted at rs12124310 and rs4915853. A single coagulation-related association is noted for rs1168114. Several additional variants, including rs10889363, rs12031537, and rs4409689, have published SNP pages but carry no trait label in the current dataset.

Evidence quality

All catalogued variants carry a uniform magnitude score of 2.20, consistent with GWAS-derived signals of modest individual effect size. The input data does not include odds ratios, beta coefficients, or sample sizes for individual variants, so precise effect magnitudes cannot be reported. Trait labels are drawn from GWAS catalogs rather than functional or clinical studies, and no ClinVar pathogenicity classifications appear in the current dataset. The recurrence of metabolic and nutritional signals across multiple independent variants at the same locus is the strongest structural feature of the evidence base, but replication across independent cohorts has not been confirmed from the available summaries. Findings should be treated as preliminary associations pending further validation.

What this is NOT

These variants represent population-level statistical signals from GWAS and do not predict any specific outcome for any individual. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.