DOCK3, variants, traits, and what the research shows

DOCK3: what this gene does

The variants catalogued for this gene are linked to two broad research areas: neurological conditions and rare diseases.

Key takeaways

• Variants in this gene appear in studies of neurological conditions and rare diseases
• Seven variants scored at the highest magnitude tier span both trait categories
• 224 variants are catalogued in total, with 17 carrying prior research summaries
• One variant has a dedicated research page in this database and is linked to neurological traits
• All associations here are population-level statistical signals, not individual health predictors

Notable variants

The highest-magnitude variants on file (magnitude is a catalogued priority score, where higher values reflect greater research attention or effect-size estimates), each scored at 5.50, include rs142515812, rs1553749681, and rs1560414254 in the neurological category, and rs148159031, rs2107262663, rs2107729763, and rs950181650 in the rare-disease category. A second tier of magnitude-5.00 variants follows, including neurological entries rs1560212751 and rs2549285187, and rare-disease entries rs1378797018 and rs2548199661. The neurological variant rs10446472, scored at magnitude 4.50, is the only one with a dedicated published page in this database.

Trait associations

Neurological conditions are a prominent trait theme, with rs142515812, rs1553749681, rs1560414254, rs1560212751, rs2549285187, and rs10446472 all assigned to this category. Rare disease associations appear with comparable frequency among the highest-magnitude entries, represented by rs148159031, rs2107262663, rs2107729763, rs950181650, rs1378797018, rs2548199661, rs1007036725, and rs1027557243. One variant, rs17659990 at magnitude 4.50, is assigned to a cancer trait category. Several magnitude-4.50 variants, including rs138144932, rs4714901, rs544108035, rs76089552, and rs879887838, do not carry trait labels in the current data set.

Evidence quality

Of 224 catalogued variants, 17 carry prior research summaries, and only one variant, rs10446472, has a published editorial page in this database, though the detail content of that page was not available for this summary. Magnitude scores reflect catalogued research priority but do not substitute for precise effect sizes - statistical measures such as odds ratios (which estimate how much a variant shifts the probability of a trait in a population) or beta coefficients (the measured change in a quantitative trait per variant copy) - or for sample sizes, none of which are available in the current input. Without replication data or cohort counts, it is not possible to distinguish robust multi-study signals from single-cohort findings. All associations should be treated as preliminary until further variant-level detail is published.

What this is NOT

The variants listed here are population-level statistical signals identified in research studies and are not deterministic predictors of any health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.