DNAH10, variants, traits, and what the research shows

DNAH10 - what this gene does

Variants catalogued in this gene are linked predominantly to rare disease traits. No functional summaries are yet available for individual variants, so the biological role cannot be characterized further from the current dataset.

Key takeaways

• Nine top-magnitude variants in this gene are all classified under rare disease traits.
• Eight of those variants share the highest recorded magnitude score of 5.50, placing them among the more notable signals on file.
• A ninth variant carries a magnitude of 5.00 and is also flagged under rare disease.
• No individual study summaries are yet available, so effect sizes and sample sizes for these associations are not reported here.
• These are population-level signals and do not predict outcomes for any individual.

Notable variants

The eight variants at the highest magnitude score of 5.50 are rs118146260, rs138151312, rs144421774, rs145614363, rs2136959456, rs2137700684, rs552141374, and rs73221409, each linked to rare disease. A ninth variant, rs759073156, carries a magnitude of 5.00 and is similarly classified under rare disease.

Trait associations

Rare disease is the sole trait theme represented in the available data. All nine top-magnitude variants detailed above share this classification. The consistency of the rare disease flag across all nine variants is notable, though without published study summaries the specific conditions or mechanisms involved cannot be described. The remaining variants at magnitude 3.00 in the dataset do not carry trait annotations.

Evidence quality

No individual SNP summaries are currently available for this gene. The associations described here are drawn from variant classification data alone, without published effect sizes, sample sizes, or replication records. The rare disease flag on the nine top-magnitude variants indicates clinical or research-level interest, but the strength of each individual association cannot be assessed from the available data. These findings should be treated as preliminary pointers to variants of interest rather than established clinical signals.

What this is NOT

These variants are population-level statistical signals and are not deterministic predictors for any individual. This page does not constitute medical advice, a diagnosis, or a recommendation of any kind.