DLGAP2, variants, traits, and what the research shows

DLGAP2 - what this gene does

Variants identified within DLGAP2 span several trait categories in published research, including neurological conditions, mental health, cancer, cardiovascular traits, rare disease, immune function, and kidney-related phenotypes. The breadth of these associations reflects the gene's appearance across genome-wide association studies (GWAS - studies that scan large numbers of genomes for variants statistically linked to a trait) covering multiple biological systems.

Key takeaways

• DLGAP2 variants have been linked to both neurological and mental health traits, with multiple independent variants pointing to each category.
• The highest-magnitude variant in this gene is associated with a rare disease phenotype, the strongest single signal on file.
• Three separate variants appear in cancer-related research, suggesting this gene shows up across diverse oncology studies.
• Associations also extend to cardiovascular, kidney, and immune traits, making this one of the more broadly studied genes in our dataset.
• All findings are population-level statistical signals and do not predict health outcomes for any individual.

Notable variants

The strongest single signal in this gene is rs376920234 (magnitude 5.50), linked to a rare disease trait, the only variant here reaching that evidence tier. Several variants cluster at magnitude 4.50: rs112455974 and rs17747701 both carry neurological associations, while rs3812479 and rs4875884 appear in mental health research. Three variants flag cancer associations, namely rs139288166, rs1875664, and rs71516114, and their independent appearance within this gene adds weight to the signal for that trait category. Rounding out the picture, rs1451882 is linked to cardiovascular traits, rs2404298 to kidney-related phenotypes, and rs137871296 to immune function.

Trait associations

Across the 187 variants catalogued for this gene, the most represented trait categories are neurological conditions (including rs112455974 and rs17747701), mental health (including rs3812479 and rs4875884), and cancer, which carries three distinct variant associations: rs139288166, rs1875664, and rs71516114. The concurrent appearance of neurological and mental health associations in separate variants may reflect overlapping biological pathways, though the available data does not establish a mechanistic link. Further associations span cardiovascular traits via rs1451882, rare disease via rs376920234, kidney-related phenotypes via rs2404298, and immune function via rs137871296.

Evidence quality

Of 187 total variants on file, 18 carry prior research summaries. The highest-magnitude variant, rs376920234 at 5.50, represents the strongest individual signal. The majority of named variants sit at magnitude 4.50, a tier consistent with GWAS associations that require replication across independent cohorts before firm conclusions can be drawn. Published editorial pages exist for rs11782720 and rs112455974, indicating these have been subject to prior review, though detailed effect sizes and replication status are not available in the current dataset. Several variants including rs138412709, rs17669535, rs181281798, rs28719689, rs549237777, rs552498380, rs556273031, and rs569880749 carry no trait label in the current dataset, which limits interpretation of their significance.

What this is NOT

These variants represent statistical associations observed at the population level in large genomic studies, not deterministic predictors of any health outcome for any individual. Nothing in this entry constitutes medical advice, a diagnosis, or a recommendation to take any action.