DLEU1, variants, traits, and what the research shows

DLEU1 - what this gene does

Based on the variants catalogued here, DLEU1 (Deleted in Lymphocytic Leukemia 1, located on chromosome 13) appears across genetic research linked to respiratory, neurological, metabolic, athletic, immune, and mental health trait categories. The available data do not provide enough mechanistic detail to characterize the gene's precise biological function, but the breadth of trait themes - spanning seven distinct categories - is notable.

Key takeaways

• Nine of this gene's catalogued variants reach the highest recorded evidence magnitude, touching respiratory, neurological, and athletic trait categories
• Metabolic associations appear across three separate variants at two different evidence levels, suggesting a recurring signal worth watching
• Neurological trait links appear in two of the highest-magnitude variants
• This gene has 192 total catalogued variants, making it one of the more densely annotated loci in this dataset
• All findings are population-level statistical associations and are not predictive for any individual

Notable variants

Among the highest-magnitude variants (4.50), rs112950911 is linked to respiratory traits and rs117887196 and rs2066591 are both linked to neurological traits - two independent signals pointing to the same trait category strengthens the case for further investigation. rs73196774 at the same magnitude is associated with athletic traits. Several additional magnitude-4.50 variants - rs112664965, rs117883255, rs201764, rs3116597, and rs60147627 - are catalogued here without a specific trait label in the current dataset. At magnitude 2.80, rs1149833 is tied to metabolic traits, rs2580188 to mental health, rs706617 to rare disease, and rs9596270 to immune function.

Trait associations

The trait landscape for this gene is broad. Respiratory associations are anchored by rs112950911 at the highest evidence magnitude. Neurological signals appear in both rs117887196 and rs2066591, and the fact that two independent variants point to the same trait category is a modest replication signal. Metabolic traits show up across three variants at two distinct evidence levels - rs1149833 at magnitude 2.80, and rs10459327 and rs111564848 at magnitude 2.20 - making metabolic traits one of the more consistently represented themes. Athletic performance traits are associated with rs73196774 at magnitude 4.50. Immune function is linked to rs9596270, mental health to rs2580188, and rare disease to rs706617, each at magnitude 2.80.

Evidence quality

Several variants - including rs112664965, rs112950911, rs117887196, rs1149833, rs1028814, rs1028862, rs10459327, rs111564848, rs113539437, and rs1149841 - have published research pages, indicating prior curation, though detailed study metadata (sample sizes, cohort count, odds ratios) are not available in the current dataset. The magnitude scores (2.20-4.50) reflect a composite of effect size and evidence strength, with 4.50 representing the top tier. The recurrence of metabolic and neurological signals across multiple independent variants is a modest positive indicator of replication, but without full study-level details, all associations should be treated as leads requiring further corroboration rather than established findings. Most signals are consistent with GWAS - genome-wide association studies that scan hundreds of thousands of genetic positions across large populations for statistical links to traits - and carry the standard GWAS caveat that association does not equal causation.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors - carrying a listed variant shifts average trait risk across populations but does not determine any outcome for a specific individual. This content is informational only; nothing here constitutes medical advice, a diagnosis, or a recommendation of any kind.