DLC1, variants, traits, and what the research shows

DLC1 - what this gene does

DLC1 (Deleted in Liver Cancer 1) has 340 variants on file, with the highest-magnitude entries linked to two broad trait themes: cancer and rare disease. Because per-variant research summaries are not yet available, specific subtypes, mechanisms, or clinical details cannot be described at this time.

Key takeaways

• This gene has 16 variants at the highest magnitude score on file (5.50), split across cancer and rare disease associations.
• Nine top-magnitude variants carry cancer trait annotations, and seven carry rare disease annotations.
• Four additional variants at magnitude 4.50 have no trait labels yet assigned.
• These are population-level statistical associations, not individual diagnostic certainties.
• Detailed per-variant summaries are pending; more specific trait descriptions will follow as that data becomes available.

Notable variants

All 16 top-tier variants score at magnitude 5.50, indicating strong signal strength within the underlying data. On the cancer side, rs121908500, rs139243841, rs146692656, rs575649250, and rs779069462 are among the nine cancer-annotated entries at this level. On the rare disease side, rs149472569, rs200118247, and rs761388824 are among the seven rare-disease-annotated entries at the same magnitude. Four further variants at magnitude 4.50 are on file without trait labels.

Trait associations

The two trait themes present in the variant data are cancer and rare disease. Nine variants, including rs121908500 and rs779069462, carry cancer-related annotations at the highest magnitude level. Seven variants, including rs149472569 and rs761388824, carry rare disease annotations at the same level. Because no per-variant summaries are available, specific cancer subtypes or rare disease names cannot be identified, and cross-variant replication cannot be assessed at this stage.

Evidence quality

The 16 top-magnitude variants all score 5.50 within the cataloguing system on file. No study-level metadata such as sample sizes, cohort counts, or effect sizes (numbers quantifying how strongly a variant is associated with a trait) are available for these entries. The four magnitude-4.50 variants have no trait annotations on file. All associations should be treated as preliminary signals until per-variant research summaries are added.

What this is NOT

These variants are population-level statistical signals, and carrying any one of them does not predict with certainty that any individual will develop cancer or a rare disease. This page does not constitute medical advice, a diagnosis, or a recommendation to take any action.