DENND2B, variants, traits, and what the research shows

DENND2B - what this gene does

DENND2B is a human gene whose variants have been identified through genome-wide association studies (GWAS - large scans that search many people's DNA for variants statistically linked to a trait) as being associated with respiratory traits. The dataset on file contains 122 variants, with the leading signals pointing to respiratory phenotypes.

Key takeaways

• This gene has 122 genetic variants on file, with the highest-magnitude signals linked to respiratory health.
• Three variants - rs10840132, rs2653606, and rs72632952 - carry the strongest evidence-weighted scores in this gene.
• The top-ranked variant, rs10840132, is the only one in the current dataset with a confirmed respiratory trait link.
• All associations are population-level statistical signals from GWAS research, not individual health predictions.
• Twenty of the 122 variants have prior published research summaries; the evidence base continues to grow.

Notable variants

The three highest-magnitude variants on file are rs10840132, rs2653606, and rs72632952, each carrying an evidence-weighted magnitude score of 4.50 - the strongest recorded for this gene. Of these, rs10840132 is the only one with a confirmed trait association in the current dataset, linked to respiratory phenotypes; it also has a dedicated published variant page. A broader tier - including rs1250776997, rs1264703954, rs1314348279, rs1359131754, and rs1366805201 among others - each carries a magnitude score of 3.00, rounding out the gene's wider variant landscape.

Trait associations

The primary trait theme documented in the available data is respiratory health. rs10840132, the top-ranked variant by combined evidence score, is the one variant with a confirmed association with respiratory phenotypes. The two other top-magnitude variants - rs2653606 and rs72632952 - do not currently carry trait labels in the available data. The many 3.00-magnitude variants, including rs146103583, rs147213924, and rs148352721, similarly lack trait metadata at this time.

Evidence quality

The best-characterized signal is rs10840132, which carries a confirmed respiratory trait link and a dedicated published variant page. The remaining two top-magnitude variants - rs2653606 and rs72632952 - currently lack trait metadata, limiting interpretation. Across the full set of 122 variants, 20 have prior research summaries; all associations are derived from GWAS methodology, which identifies statistical correlations at the population level rather than establishing direct causal mechanisms. Effect sizes, odds ratios, and cohort sizes are not available in the current dataset, so the practical magnitude of individual findings cannot be precisely quantified. Unreplicated findings should be treated as preliminary.

What this is NOT

These variants represent population-level statistical associations and are not deterministic predictors of any health outcome for any individual person. This entry does not constitute medical advice, a diagnosis, or a recommendation for any course of action.