DENND1B, variants, traits, and what the research shows

DENND1B - what this gene does

DENND1B has variants linked primarily to mental health and neurological trait themes in genome-wide association studies (GWAS - studies that scan many people's genomes for variants statistically associated with a trait). Based on available variant data, the clearest signals point toward these two broad domains, though detailed mechanistic information is not present in the current evidence base.

Key takeaways

• Multiple high-magnitude DENND1B variants are associated with mental health traits, with several independent hits suggesting a recurring signal
• Neurological trait associations appear across more than one variant, adding a second brain-related domain
• All associations here are population-level GWAS signals, not deterministic predictions for any individual
• The gene has 75 variants on file, indicating it is a well-studied region in genetic research
• Specific effect sizes and replication details are limited in the current published summaries

Notable variants

The highest-magnitude variants (4.50) include several with clearly tagged trait associations. rs10754228, rs2477059, and rs2488401 each carry mental health trait tags. rs112883537 and rs113406856 are each tagged to neurological traits. Also at magnitude 4.50, rs10737693, rs12120143, rs190073601, and rs2488398 are on file, though their specific trait tags are not present in the current dataset.

Trait associations

Mental health traits appear across three independent magnitude-4.50 variants (rs10754228, rs2477059, and rs2488401), suggesting a genuine recurring signal in this domain rather than a single isolated finding. Neurological traits are flagged independently for rs112883537 and rs113406856, a second theme appearing across distinct variants within the same gene. The co-occurrence of mental health and neurological signals across multiple independent variants strengthens the case that this gene region is relevant to brain-related trait variation, though specific conditions and effect sizes remain to be characterized from the full per-variant data.

Evidence quality

This gene has 75 variants on file with 18 carrying prior research summaries, a moderate evidence base by GWAS standards. The top-tier magnitude scores (4.50) across the mental health and neurological clusters suggest these signals have been flagged as noteworthy in the literature. However, specific sample sizes, odds ratios, and replication cohort details are not provided in the current summaries, so the strength of individual associations cannot be fully characterized from available data. All findings should be treated as preliminary pending comprehensive per-variant documentation.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies, not deterministic predictors of any individual's health or behavior. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.