DENND1A, variants, traits, and what the research shows

DENND1A - what this gene does

Variants catalogued for DENND1A span four main trait themes identified in GWAS (genome-wide association studies - large-scale scans that search thousands of people's genomes for variants statistically linked to specific traits): hormonal regulation, nutrition-related outcomes, kidney function, and mental health. The specific molecular role of this gene cannot be further characterized from the available variant data alone.

Key takeaways

• Variants in this gene are linked to hormonal traits across multiple high-magnitude signals
• Nutrition-related outcomes are associated with at least one high-magnitude variant in this gene
• Kidney function is among the trait themes represented in this gene's variant data
• Mental health associations have also been flagged in research connected to this gene
• All signals here are population-level statistical findings - not predictors for any one individual

Notable variants

Fifteen variants in this gene sit at the highest magnitude tier on file (4.50), reflecting the strongest combination of effect size and evidence strength in this dataset. Among the annotated subset, rs10986105 is flagged for hormonal trait associations and rs113977954 is connected to nutrition-related outcomes. Kidney function signals appear via rs62579196, while mental health associations are represented by rs6478623. Two additional magnitude-4.50 variants - rs10986064 and rs12377595 - have published research pages, though their specific trait annotations are not available in the current dataset.

Trait associations

Across the 147 variants catalogued for this gene, four trait themes emerge from the annotated subset. Hormonal traits are linked through rs10986105. Nutrition-related outcomes appear via rs113977954. Kidney function is flagged by rs62579196. Mental health associations are represented by rs6478623. The majority of the high-magnitude variants in the dataset do not yet carry individual trait annotations, meaning the full breadth of associations for this gene may extend well beyond what is currently documented here.

Evidence quality

The 15 highest-magnitude variants reach a score of 4.50, with a further 5 variants at magnitude 3.00, across a total of 147 variants on file. All signals in this entry are GWAS-derived population-level associations; only 23 of the 147 variants have prior research summaries on file, and detailed editorial content was not available for the four variants with published pages at the time of this writing. Without replication data or functional validation explicitly documented in the current dataset, these findings are best treated as hypothesis-generating leads rather than confirmed associations. Single-cohort findings - those drawn from one population sample, without independent repeat confirmation - are common at this evidence tier and should be interpreted with additional caution.

What this is NOT

These variants are population-level statistical signals discovered in large genetic studies, not deterministic predictors of any disease, trait, or outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.