CREB5, variants, traits, and what the research shows

CREB5 - what this gene does

Based on the variants catalogued here, CREB5 shows up in genome-wide association studies (GWAS - studies that scan large numbers of people's genomes for variants statistically linked to a trait) across four broad trait areas: mental health, neurological conditions, immune function, and respiratory health.

Key takeaways

• Variants in this gene have been associated with four trait areas: mental health, neurological function, immune response, and respiratory health.
• The six highest-magnitude variants in this catalogue include associations with all four of these trait themes.
• Most signals in this catalogue are GWAS-level findings, which reflect patterns across large populations rather than predictions for any one person.
• Study summaries for 17 of the 149 catalogued variants are pending inclusion and are not yet reflected in this page.
• No effect sizes or replication data are available in the current dataset, so all findings should be treated as preliminary.

Notable variants

The six variants scored at the highest magnitude in this catalogue span the gene's main trait themes. rs10238623 is linked to a mental health trait, and rs42714 carries a neurological association. rs59131815 is associated with an immune trait, while rs79835348 is tied to a respiratory trait. Two further top-magnitude variants, rs73077895 and rs7799265, are catalogued at the same signal strength but carry no trait labels in the current dataset.

Trait associations

The variant catalogue spans four trait themes. A mental health association is represented by rs10238623. A neurological association appears via rs42714. An immune-related association is catalogued for rs59131815. A respiratory association is on record for rs79835348. A broader set of lower-magnitude variants, including rs114327290, rs115644935, rs143789664, and others, are catalogued at magnitude 3.00 but currently carry no trait labels.

Evidence quality

Study summaries are pending for 17 of the 149 catalogued variants; none are reflected in the current version of this page. The trait labels attached to the top-magnitude variants, rs10238623, rs42714, rs59131815, and rs79835348, represent preliminary GWAS-level signals only. Without effect sizes or replication data, the strength of each association cannot be independently assessed, and all findings should be treated as preliminary until full summaries are published.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies, not deterministic predictors of any outcome for any individual. This page does not prescribe, diagnose, or advise any course of action.