CRADD, variants, traits, and what the research shows

CRADD - what this gene does

Variants catalogued in CRADD span three broad trait themes - rare disease, cardiovascular, and respiratory - based on the association data on file. The highest-magnitude signals concentrate in the rare disease category, while additional variants link to cardiovascular, respiratory, and liver contexts.

Key takeaways

• Six of the top-ranked CRADD variants share the highest magnitude score on file, all linked to rare disease traits.
• A cardiovascular-associated variant appears among the higher-confidence findings.
• Two separate respiratory-linked variants suggest tentative within-gene replication of that signal.
• A liver association rounds out a broad trait profile for a single gene.
• All signals are population-level statistical associations - not deterministic predictors for any individual.

Notable variants

Six variants - rs141179774, rs1555213545, rs387906861, rs749655461, rs764518202, and rs772665884 - carry the highest magnitude score on file (5.50), all linked to rare disease traits. Just below them, rs1207931375 and rs1956612435 (magnitude 5.00) are also associated with rare disease, while rs2540635374 (magnitude 5.00) links to a cardiovascular trait. Among the mid-tier signals, rs10859579 and rs11107184 (both magnitude 4.50) associate with respiratory traits, and rs10859604 (magnitude 4.50) associates with a liver trait.

Trait associations

The dominant theme in this gene's variant landscape is rare disease: at least ten variants across the magnitude range carry this designation, including the highest-scoring cluster of rs141179774, rs1555213545, rs387906861, rs749655461, rs764518202, and rs772665884, as well as rs1207931375, rs1956612435, rs150059138, and rs1958201153. A cardiovascular signal is present via rs2540635374. The respiratory trait appears across two independent variants - rs10859579 and rs11107184 - which provides tentative within-gene replication of that association. A liver association is noted at rs10859604. Several lower-magnitude variants - including rs1431834925, rs147581583, rs1592870753, rs1955220368, rs1958194482, and rs1958197804 - have no trait metadata on file.

Evidence quality

The strongest signals in this dataset (magnitude 5.50) are confined to rare disease associations across six variants. The cardiovascular, respiratory, and liver signals at magnitude 4.50-5.00 are each represented by individual variants; no sample sizes, odds ratios, or cohort replication details are available in the current dataset, making it difficult to assess the depth of evidence behind these associations independent of magnitude score. The two respiratory variants rs10859579 and rs11107184 - sharing the same trait label and the same magnitude - offer the clearest indication of within-gene signal replication; all other trait associations rest on a single variant only. Published editorial summaries for the three variants with dedicated pages - rs10859579, rs10859604, and rs11107184 - are not yet available, which limits deeper characterization of those signals. GWAS (genome-wide association study - a method that scans large numbers of people's genomes for variants statistically linked to a trait) findings in particular should be treated as preliminary until independently replicated.

What this is NOT

These variants represent population-level statistical signals, not deterministic predictors of disease or health outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.