CR1, variants, traits, and what the research shows

CR1 - what this gene does

Variants in the CR1 gene have been catalogued in connection with three broad trait themes: rare disease, neurological conditions, and cardiovascular conditions. Because no detailed study summaries are yet available for this gene, specific mechanisms and disease names cannot be confirmed from the data on file.

Key takeaways

• CR1 carries variants linked to rare disease, neurological, and cardiovascular trait categories.
• The five highest-magnitude signals in this gene all fall in the rare disease category.
• Two separate neurological-tagged variants and one cardiovascular-tagged variant reach the next tier of signal strength.
• 128 variants are on file for this gene, with detailed study summaries still being added.
• All associations here are population-level statistics, not individual health predictions.

Notable variants

The five highest-magnitude variants on file - rs140566582, rs199990810, rs200399748, rs202148801, and rs368350236 - all reach a magnitude of 5.50 and are tagged with the rare disease trait category, representing the strongest signals catalogued for this gene. Two neurological-tagged variants, rs2093760 and rs6656401, reach magnitude 4.50, as does one cardiovascular-tagged variant, rs61034679. A further group of variants - including rs1037377565, rs1045757587, and rs1160995265 among others - carry magnitude 3.00 signals without specific trait labels yet assigned.

Trait associations

The three trait themes represented in this gene's variant list are rare disease, neurological conditions, and cardiovascular conditions. The rare disease category holds the highest-magnitude signals, with five variants - rs140566582, rs199990810, rs200399748, rs202148801, and rs368350236 - all scoring at magnitude 5.50. Neurological associations appear in rs2093760 and rs6656401 at magnitude 4.50, and a cardiovascular association appears in rs61034679 at the same level. Specific condition names within these broad categories are not yet documented in the summaries on file.

Evidence quality

No detailed study summaries - including sample sizes, replication status, or effect sizes such as odds ratios (a measure of how much a variant changes the statistical likelihood of a trait in a studied population) - are yet available for variants in this gene. Magnitude scores reflect a composite of effect size and evidence strength, but without underlying study metadata the basis for each score cannot be independently verified here. The signals at magnitude 5.50 suggest the strongest statistical associations in this dataset, but whether they derive from replicated multi-cohort GWAS (genome-wide association studies - scans of many people's genomes for variants statistically linked to a trait) or single-cohort findings is not determinable from the data on file. All findings should be treated as preliminary until study-level details are documented.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors of disease or health outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.