CHRNB4, variants, traits, and what the research shows

CHRNB4 - what this gene does

Based on the variants catalogued here, CHRNB4 shows associations spanning neurological traits and cancer, with the strongest signals concentrated in the neurological category.

Key takeaways

• Two CHRNB4 variants carry the strongest neurological signals in the gene's entire 100-variant catalog.
• A separate variant links this gene to cancer risk, though detailed study data is not yet available to characterize the specific cancer type.
• Three independent variants with neurological trait tags hint at a consistent signal, though replication data is still pending.
• Detailed study-level information - sample sizes, odds ratios, and replication cohorts - is not yet available for any catalogued variant.
• Population-level associations in this gene do not predict outcomes for any individual.

Notable variants

The two highest-magnitude variants on file are rs2141385401 and rs774714066, both scoring a magnitude of 5.00 and both linked to neurological traits - representing the strongest signals in this gene's current dataset. A third neurological-linked variant, rs548549089, registers at magnitude 3.00. On the cancer side, rs2542849908 is the sole variant with a cancer trait tag, also at magnitude 3.00. Additional moderate-evidence variants including rs138297812, rs181037724, rs373261379, rs540605951, and rs757621997 each carry magnitude 3.00 scores but have not yet been paired with specific trait labels in the current dataset.

Trait associations

The dominant trait theme in this gene's variant catalog is neurological: rs2141385401 and rs774714066 both carry neurological trait tags at the highest observed magnitude in this gene (5.00), and rs548549089 adds a third neurological data point at magnitude 3.00. The appearance of the same trait category across three independent variants strengthens - though does not confirm - the neurological signal, as cross-variant replication within a gene is generally considered more informative than a single isolated hit. Cancer appears as a secondary theme via rs2542849908; with only one cancer-tagged variant and no supporting summary data, this association should be treated as preliminary.

Evidence quality

Detailed study-level information - including sample sizes, odds ratios, and replication status - is not yet available for any of the 100 catalogued variants in this gene; the current dataset reflects variant index entries rather than peer-reviewed research summaries. The two magnitude-5.00 variants (rs2141385401 and rs774714066) represent the strongest signals by the internal magnitude score, but without underlying study metadata those scores cannot be benchmarked against standard GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically associated with a trait) criteria such as genome-wide significance thresholds or multi-cohort replication. All associations described here should be considered preliminary until full summary data is published and linked.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual. This page does not prescribe, diagnose, or advise any course of action.