CDC42BPA, variants, traits, and what the research shows

CDC42BPA -- what this gene does

Based on the variants on file, CDC42BPA is a human gene whose documented variants span two broad trait areas: cardiovascular health and mental health. The highest-magnitude signals in the dataset fall across both categories, placing this gene's locus on the radar of genome-wide association studies (GWAS -- studies that scan many people's genomes for variants statistically associated with a trait) in both domains.

Key takeaways

• Four variants reach the highest magnitude score in the dataset, spanning cardiovascular and mental health trait categories
• Two independent cardiovascular variants appear at the top evidence tier, which is consistent with a potentially replicated signal within this locus
• A mental health variant at the same top magnitude tier adds a second trait dimension
• 116 total variants are on file, with 17 carrying prior research summaries
• All associations are population-level GWAS signals, not individual-level predictors

Notable variants

The four top-tier variants all reach a magnitude score of 4.50. rs112282634 and rs115346894 have published reference pages, with rs115346894 specifically linked to cardiovascular traits. rs139496757 also carries a cardiovascular association at the same magnitude tier, and rs7556248 is linked to mental health traits at magnitude 4.50. Among the magnitude-3.00 group, variants including rs142464333, rs145018031, rs146651448, rs146827361, and rs200713147 extend the association footprint further across the locus.

Trait associations

Cardiovascular health is the most prominently represented trait category among the top-magnitude variants. Both rs115346894 and rs139496757 are tied to cardiovascular phenotypes at magnitude 4.50, and the appearance of two independent cardiovascular hits at the same evidence tier is consistent with a potentially replicated signal within this locus, though the specific cardiovascular endpoints and study cohorts are not detailed in the currently available data. Mental health associations are represented by rs7556248 at the same top magnitude level. The gene's 116 total variants on file, with 17 carrying prior research summaries, suggest a broad pattern of association that extends beyond these four headline signals.

Evidence quality

The strongest signals reach a magnitude score of 4.50, and two of those -- rs112282634 and rs115346894 -- have published reference pages. The cardiovascular trait theme is supported by at least two independent magnitude-4.50 variants, which is a modest indicator of replication within this locus. However, specific study sample sizes, odds ratios, beta coefficients, and cohort details are not available in the current input, which limits any assessment of effect size or cross-population generalizability. The majority of the 116 variants on file sit at magnitude 3.00, indicating weaker individual signals relative to the top tier. Without published summary statistics for most variants, the strength of association for specific trait endpoints remains uncharacterized here.

What this is NOT

These variants are population-level statistical signals from genome-wide association studies, not deterministic predictors of any condition for any individual. This content does not constitute medical advice, diagnosis, or treatment recommendations of any kind.