CD36, variants, traits, and what the research shows

CD36 - what this gene does

CD36 (also known as FAT, GPIV, PASIV, and SCARB3) is a human gene whose catalogued variants cluster around three trait themes: coagulation (the biological process by which blood forms clots), cardiovascular function, and rare disease. No detailed functional summaries are yet available for the specific variants on file, so the gene's role here is characterized by the trait categories observed across 249 catalogued variants.

Key takeaways

• Variants in this gene are most consistently linked to coagulation - the process by which blood forms clots - which accounts for the large majority of the top-ranked entries.
• A smaller cluster of variants is associated with cardiovascular traits.
• Two variants carry rare disease annotations.
• All top-listed variants share the same evidence-weight score, suggesting a consistent signal tier across the set.
• These are population-level statistical associations, not deterministic predictors for any individual.

Notable variants

The top coagulation-linked entries include rs121918035, rs138897347, rs5956, rs754365623, and rs142186404, all at magnitude 5.50. On the cardiovascular side, rs3211893 and rs545489204 share the same magnitude tier. Two variants - rs751471043 and rs752886472 - are flagged under rare disease categories.

Trait associations

The dominant trait theme is coagulation, with sixteen of the twenty listed variants carrying that annotation: rs121918035, rs138897347, rs141626483, rs142186404, rs146027667, rs148114593, rs149985988, rs185913608, rs188717259, rs200067322, rs201657731, rs5956, rs745604189, rs748431584, rs749415195, and rs754365623. Two variants - rs3211893 and rs545489204 - are associated with cardiovascular traits, and two - rs751471043 and rs752886472 - carry rare disease annotations.

Evidence quality

All twenty listed variants share a uniform magnitude score of 5.50, indicating a consistent evidence-weighting tier within the dataset. However, no detailed SNP summaries - including sample sizes, odds ratios, replication status, or study design information - are currently available for this gene. Without that underlying metadata it is not possible to assess whether these findings originate from large multi-cohort GWAS studies (genome-wide association studies - large scans that test many genomic positions for statistical links to a trait) or smaller single-cohort investigations. Of 249 total variants on file, only 20 are represented in the current list; the full dataset may carry additional trait signals or a broader evidence range.

What this is NOT

These variants represent population-level statistical associations and are not deterministic predictors for any individual. This content does not constitute medical advice, a diagnosis, or a recommendation to take any action.