CCND3, variants, traits, and what the research shows

CCND3 - what this gene does

Variants in CCND3 have been catalogued across published research in association with four trait themes: mental health, immune function, cancer, and coagulation - areas identified through GWAS (genome-wide association studies, which scan large numbers of people's genomes for variants statistically linked to a trait).

Key takeaways

• CCND3 has variants statistically linked to mental health, immune function, cancer, and coagulation traits.
• Four of the highest-magnitude variants each score 4.50 - the peak tier in this dataset - spanning three distinct trait areas.
• Coagulation is the only trait supported by more than one independent variant entry, offering a modest convergent signal.
• 126 variants are on file in total; 21 carry prior published research summaries.
• All findings are population-level statistical associations, not predictors of outcomes for any individual.

Notable variants

The four highest-magnitude entries - rs12214723 (mental health), rs73733067 (immune), rs74979086 (cancer), and rs12661263 (trait detail not on file) - each reach magnitude 4.50, the highest tier recorded in this dataset. A mid-tier cluster at magnitude 3.00 includes rs1353553597, rs374294883, rs750688882, and rs759741362, though trait labels are not available for these entries. At magnitude 2.20, rs10456506 and rs10807272 are both linked to coagulation, while rs1051129, rs10947997, and rs10948001 carry published pages.

Trait associations

The traits on file span four areas. Mental health associations appear through rs12214723. Immune-related traits surface via rs73733067. Cancer associations are represented by rs74979086. Coagulation is the only theme supported by more than one variant here - both rs10456506 and rs10807272 point to it - which provides a modest degree of convergent signal within the dataset compared with the single-variant signals for the other three trait themes.

Evidence quality

The highest-magnitude variants reach 4.50, placing them among the stronger signals on file, but specific effect sizes (such as odds ratios or beta coefficients), sample sizes, and cross-cohort replication status are not available in the input data provided here. The coagulation trait has two independent variant entries (rs10456506 and rs10807272), which is the closest thing to within-gene replication visible in this dataset; all other trait associations rest on single-variant signals. Full study-level detail, where available, can be found on the individual SNP pages for the 21 variants with published summaries.

What this is NOT

These variants are population-level statistical signals from GWAS studies - they are not deterministic predictors of any health outcome for any individual. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.