CCDC170, variants, traits, and what the research shows

CCDC170 - what this gene does

Variants catalogued for CCDC170 (coiled-coil domain containing 170) span four broad trait themes - rare disease, mental health, blood coagulation, and cancer - though no detailed research summaries are currently on file, limiting characterisation to the trait labels associated with each variant.

Key takeaways

• The highest-ranked variant on file points to a rare disease association.
• Two independent mental-health-linked variants carry the same moderate signal strength, providing limited within-gene replication.
• Separate variants flag associations with blood coagulation and cancer.
• A larger cluster of lower-ranked variants currently lacks trait labels, suggesting the full scope of associations is still being characterised.
• All findings are population-level statistical associations, not deterministic predictions for any individual.

Notable variants

The strongest signal on file is rs55868409 (magnitude 5.50), associated with a rare disease trait. Mental health associations appear at rs141252918 and rs149389640, each at magnitude 4.50 - the fact that two distinct variants share this trait category within the same gene adds modest support to that signal. A coagulation-linked variant, rs202125938, and a cancer-linked variant, rs4869742, both reach magnitude 4.50 as well. A further cluster - including rs1782580442, rs183044234, rs199826959, and rs200402314 - sits at magnitude 3.00 with no trait annotation currently on record.

Trait associations

Four trait domains surface across the top-ranked variants. In rare disease, rs55868409 carries the largest magnitude score on file. Mental health is represented by two variants - rs141252918 and rs149389640 - making it the only category with more than one supporting variant in current records; this dual signal, while not conclusive, is more notable than any single-variant finding. Blood coagulation is flagged by rs202125938, and cancer by rs4869742; both stand on single-variant evidence only.

Evidence quality

No underlying research summaries - study design, sample sizes, effect sizes, or replication status - are currently attached to any variant in this gene. The available record is a ranked variant list with trait-category labels and magnitude scores. Magnitude 5.50 for rs55868409 is the ceiling on file; whether that reflects a large GWAS (a study that scans many people's genomes for variants statistically associated with a trait), a ClinVar pathogenicity call, or a single-cohort finding cannot be determined from the data at hand. All associations should be treated as preliminary until detailed summaries become available.

What this is NOT

These variants represent population-level statistical signals, not deterministic predictors of any health outcome for any individual. This content does not constitute medical advice, a diagnosis, or a recommendation to take any action.