BSN, variants, traits, and what the research shows

BSN - what this gene does

Research data on file for BSN covers three broad trait themes: cardiovascular health, neurological conditions, and mental health. Variants in this gene have been flagged through GWAS (genome-wide association studies - large scans that look for statistical links between genetic variants and traits across many people's genomes) across all three areas, with paired independent signals in both the neurological and mental health domains suggesting associations that cross more than one biological system.

Key takeaways

• 348 variants are on file, with the five highest-magnitude signals spanning cardiovascular, neurological, and mental health traits.
• Two independent top-tier variants are linked to neurological traits and two others to mental health - each pair representing separate signals pointing to the same domain.
• One top-tier variant is associated with a cardiovascular trait.
• A lower-magnitude variant is flagged for a rare disease association.
• No effect sizes, sample sizes, or replication details are yet on file; all associations should be treated as preliminary.

Notable variants

The five highest-magnitude variants each carry a score of 4.50. rs143311886 is associated with a cardiovascular trait. rs1826347 and rs7614725 are both linked to neurological traits, representing the two strongest neurological signals in the dataset. rs6797299 and rs7625857 are each linked to mental health traits - two independent top-tier signals pointing to the same domain. At a lower magnitude tier, rs1164870159 carries a rare disease association. The remaining magnitude-3.00 variants on file, including rs1002210592, rs1008057765, and others, do not yet have trait labels in this dataset.

Trait associations

The variant data touches three main areas. Cardiovascular associations appear through rs143311886. Neurological associations appear through rs1826347 and rs7614725; having two independent top-tier signals in the same domain adds modest weight to this theme compared to a single hit. Mental health associations similarly appear in two independent top-tier variants, rs6797299 and rs7625857. A rare disease signal is flagged at rs1164870159 in the lower-magnitude tier. The remaining variants on file have not yet been characterized with trait labels in this dataset.

Evidence quality

No full SNP research summaries are yet available for this gene in this dataset, meaning effect sizes, odds ratios, sample sizes, and replication status are not on record here. The five magnitude-4.50 variants represent the strongest signals in the current data, and the presence of two independent signals each in the neurological and mental health domains is noteworthy, but all associations should be treated as preliminary until supporting detail is available. The broader set of 348 variants on file is largely uncharacterized, which means the full trait picture for this gene remains incomplete.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual. Nothing in this entry constitutes medical advice, a diagnosis, or a recommendation to take any action.