ARID5B, variants, traits, and what the research shows

ARID5B - what this gene does

Variants at the ARID5B locus are associated with cancer, kidney function, respiratory traits, and rare disease phenotypes - these recurring trait themes across the variant record define the clearest available picture of this gene's reach in population-level research.

Key takeaways

• Multiple high-magnitude variants at this locus point to cancer risk signals
• Two variants are independently linked to kidney-related traits
• A respiratory phenotype association is on file at this gene
• Rare disease phenotypes are represented by at least two variants
• All associations are population-level statistical signals, not individual risk predictions

Notable variants

The highest-priority entries all carry magnitude 4.50. Cancer-linked variants include rs10821936, rs4245595, rs7089424, and rs79965349. Kidney trait associations appear at rs112779912 and rs147430423. A respiratory association is recorded for rs35809595, and rs79498125 carries a rare disease signal. rs10995016, rs1806771, and rs4245596 also reach magnitude 4.50 without a specific trait label in the current record.

Trait associations

Cancer is the most represented trait theme, with four distinct magnitude-4.50 variants - rs10821936, rs4245595, rs7089424, and rs79965349 - all pointing to this domain. The recurrence across four independent variants is the strongest pattern in this dataset. Kidney-related traits are supported by two separate variants: rs112779912 and rs147430423. A respiratory phenotype is associated with rs35809595. Rare disease context is represented among the top-tier entries by rs79498125, and in the secondary tier by rs1053149301.

Evidence quality

The eleven highest-priority variants all reach magnitude 4.50, consistent with signals from well-powered GWAS studies - genome-wide association studies, a research design that scans large populations for genetic variants statistically tied to a trait. The full variant record contains 152 entries at this locus, with 27 having prior research summaries on file, indicating a moderately well-characterized gene. Trait-level detail is absent for three of the top-tier entries - rs10995016, rs1806771, and rs4245596 - which limits interpretation of those specific signals. Individual effect sizes and cohort details are not available in the current record for any variant listed here.

What this is NOT

These variants are population-level statistical associations drawn from large research studies, and carrying any one of them does not predict disease or health outcomes for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.