ARHGAP15, variants, traits, and what the research shows

ARHGAP15 - what this gene does

ARHGAP15 is a human gene whose variant catalogue, spanning 164 entries in current research databases, surfaces connections across mental health, liver, respiratory, rare disease, and cardiovascular trait domains in population-level genetic studies. Because the published summaries for individual variants in this gene are not yet available, this entry characterises the gene by the trait themes its variants are linked to rather than by a specific molecular mechanism.

Key takeaways

• Five separate high-magnitude variants independently link this gene to mental health traits - the most replicated association visible in the current dataset
• Three variants carry rare-disease associations at the same top evidence tier
• Distinct high-magnitude variants connect the gene to liver, respiratory, and cardiovascular traits
• All top-tier variants share a magnitude score of 4.50, suggesting comparable effect-size and evidence strength across trait domains
• These are population-level statistical signals from genetic studies - they do not predict any individual's health outcome

Notable variants

The highest-magnitude signals in this gene are concentrated in mental health and rare disease. Five variants at the top recorded magnitude - rs10048736, rs10189912, rs10191758, rs12998761, and rs4233566 - all carry mental health associations. Rare-disease signals of equal magnitude appear through rs13411140, rs145441368, and rs35942385. Beyond these, rs10928182 marks a liver-trait signal, rs12691682 appears in respiratory research, and rs2381456 surfaces in cardiovascular studies - all at the same top magnitude tier of 4.50.

Trait associations

Mental health is the dominant theme in this gene's variant profile. Five independent magnitude-4.50 variants - rs10048736, rs10189912, rs10191758, rs12998761, and rs4233566 - converge on this trait domain; multi-variant convergence on a single trait is considered a stronger circumstantial signal than any single finding alone, though it does not establish causality. Rare disease is the second most represented domain, with rs13411140, rs145441368, and rs35942385 all flagged in that category. Single high-magnitude variants point independently to liver traits (rs10928182), respiratory conditions (rs12691682), and cardiovascular phenotypes (rs2381456). Additional top-magnitude variants - rs10176394, rs144449054, rs35789697, and rs4662209 - appear in the top tier without specific trait annotations in the current dataset.

Evidence quality

Of 164 variants catalogued for this gene, 27 have associated research summaries and five - rs10928182, rs10189912, rs10048736, rs10191758, and rs10176394 - have published editorial pages; detailed effect sizes, odds ratios, and cohort sample sizes are not available in the current summary inputs. All top-tier variants share a magnitude score of 4.50, reflecting combined effect-size and evidence-strength weighting as scored by this database. The mental health association is the most internally replicated signal - five independent variants pointing to the same trait domain provides stronger circumstantial support than any single-variant finding. Lower-magnitude variants (scored at 3.00) lack trait annotations in the current dataset, limiting what can be said about the broader variant landscape. All associations should be treated as preliminary until cohort-level replication data are available.

What this is NOT

These variants are population-level statistical associations from GWAS - genome-wide association studies (large scans of many people's genomes for variants statistically linked to traits) - and are not deterministic predictors of any individual's health outcomes. This page is informational only; we do not prescribe, diagnose, or advise.