ADAMTS7, variants, traits, and what the research shows

ADAMTS7 - what this gene does

Variants in ADAMTS7 cluster around two broad trait themes visible in the genomic data on file: rare disease phenotypes and cardiovascular traits. The available variant records do not provide enough mechanistic detail to characterize the gene's molecular function, but the pattern of associations across the highest-magnitude entries is consistent across both categories.

Key takeaways

• ADAMTS7 carries variants flagged for both rare disease and cardiovascular trait associations.
• The two highest-ranked variants by magnitude are both linked to rare disease.
• A separate cardiovascular signal is also present, suggesting the gene may be relevant across more than one disease area.
• Most of the 218 variants on file sit at a lower magnitude tier and have not yet been characterized with published trait detail.
• These are population-level statistical associations, not individual predictions.

Notable variants

rs145671340 and rs61754850 are the highest-magnitude variants on file for this gene, each scoring 5.50, and both are associated with rare disease phenotypes. rs11630236 and rs28699256 both sit at magnitude 4.50: rs11630236 has a dedicated research page, while rs28699256 carries the primary cardiovascular signal in this dataset. rs181355383 reaches the same 4.50 tier but does not yet carry a trait label in the current records. A further cluster - including rs111544126, rs138120107, rs138755716, and rs139112621 - sits at magnitude 3.00, indicating earlier-stage or lower-confidence signals.

Trait associations

The variant evidence for this gene falls into two themes. The rare disease category is anchored by the highest-magnitude entries: rs145671340 and rs61754850, with both reaching a magnitude of 5.50. The cardiovascular theme is carried by rs28699256 at magnitude 4.50. The remaining magnitude 3.00 variants - including rs111544126, rs1053585286, rs138786978, rs139513941, and others - do not yet carry specific trait labels in this dataset, leaving the full breadth of the gene's phenotypic associations to be characterized by future research.

Evidence quality

The two strongest signals, rs145671340 and rs61754850, carry the highest magnitude scores in this dataset at 5.50, though specific effect sizes and cohort sample sizes are not available in the current records. rs28699256 and rs11630236 occupy the next tier at magnitude 4.50. Of 218 total variants on file, only 23 carry prior research summaries, and trait metadata is absent for the majority of the magnitude 3.00 entries - meaning the phenotypic picture remains incomplete and should be interpreted with caution. No multi-cohort replication data or odds ratios are available in the current input, which limits the strength of any conclusions drawn from this gene's variant set.

What this is NOT

These variants are population-level statistical signals identified through GWAS (genome-wide association studies - research that scans large populations for variants statistically linked to a trait), not deterministic predictors for any individual. This page is informational only; we do not prescribe, diagnose, or advise any course of action.